Threshold

Tuesday's lecture has been postponed for today due to a projector malfunction.

Equilibrium Potentials

Recall the equation for the membrane potential in the Hodgkin-Huxley model:

$C \frac{dV}{dt} = I(t) - g_L (V(t) - E_L) - g_{Na} m^3(t) h(t) (V(t) - E_{Na}) - g_K n^4(t) (V(t) - E_K)$

You can find the equilibrium potential for given channel conductances. Set the injected current to zero I = 0. Then fix and absorb the gating variables and maximal conductances $(g_L, g_{Na}, g_{K})$ into single conductance variables $(G_L, G_{Na}, G_{K})$.

For example

$G_{K} = g_K n^4$

Then the differential equation for the membrane is

$C \frac{dV}{dt} = - G_L (V - E_L) - G_{Na} (V - E_{Na}) - G_K (V - E_K)$

The equilibrium potential is the value of V such that $\frac{dV}{dt}$ is zero. You can plug in $\frac{dV}{dt} = 0$ and solve for $V_{equilibrium}.$

$V_{equilibrium} = \frac{G_L E_L + G_{Na} E_{Na} + G_K E_K}{G_L + G_{Na} + G_K}$

The equilibrium potential is the weighted average of the reversal potentials -- weighted by the corresponding conductances. Note that the weights add to one.

Now we can talk about the homework due Monday night.

And the homework due Wednesday night.